Kidney disease is a condition that defines the damage to the kidneys making these organs unable to process the blood and retain fluids and electrolytes as well as blood pressure. It includes various conditions such as chronic kidney disease (CKD), acute kidney injury, genetic disorders such as polycystic kidney disease, inflammatory diseases such as glomerulonephritis and lupus nephritis, as well as infections, toxins, and autoimmune reactions damage. The most common type is CKD, which is characterized by slow and progressive renal failure of the kidney that may result in kidney failure needed by dialysis or a transplant in case it is not treated. Diabetes and high blood pressure are the most common causes of CKD and damage blood vessels in the kidney in the long run. The symptoms usually manifest slowly and they can be characterized by fatigue, swelling, urinary alterations, and other severe symptoms such as nausea and fluid retention, as the disease advances. Early diagnosis and treatment are extremely important in delaying the disease process as well as preventing complications.